Dr. Purabi Deka Bose
Assistant Professor
Ph.D. : University of Delhi (2011)Research Interests:
Molecular Virology, Reproductive Immunology and Molecular genetics in hepatologyDate of Joining : Nov 18, 2015
Phone: 8876050090
Email: pdbose@cottonuniversity.ac.in
About
Joined as Founding Head i/c and Founding Faculty, Department of Molecular Biology and Biotechnology, Cotton University
PhD thesis tiltle: Role of Progesterone Receptor and its Associated Genes in Hepatitis E Virus Related Liver Diseases During Pregnancy
M. Sc. in Biotechnology (2002), Gold medallist, Gauhati University
CSIR-UGC NET (LS) in Life sciences (twice in 2003, 2004)
GATE Life Sciences, 2004 (93.76 PC)
B Sc. (Zoology Major), 2000, Handique Girls’ College, Guwahati
Teaching
Teaching Experience: (11 years and 8 months)
Assistant Professor (Adhoc) from 31-10-2011 to 17-11-2015 in Pandu College, Guwahati
Assistant Professor from 18-11-2015 till date in Cotton University
Experience
Research Experience
1. Acted as ICMR-SRF from 1-11-2008 to 20-12-2009 in LNJP hospital, Maulana Azad Medical College, New Delhi, and worked on "Hepatitis E related pregnancy", under the supervision of Prof Premashis Kar, former Dean of Medical Sciences, Delhi University.
Expertise: Real Time PCR techniques for viral load estimation, genotyping of Hepatiti E Virus, ELISA, gradient PCR, Immunohistochemistry
2. Acted as ICMR-SRF from 1-09-2005 to 31-08-2008 in LNJP hospital, MAMC, New Delhi and worked on " Polymorphism of NAT2 gene in ATT Induced Hepatitis" under the supervision of Prof Premashis Kar, former Dean of Medical Sciences, Delhi University
Expertise: PCR-RFLP based analysis of NAT2 gene, nucleotide sequencing
3. Acted as DBT-JRF from 01-12-2004 to 29-08-2005 in IIT Guwahai and worked on "Construction of genomic library of soil microbial isolates" under the supervision of Prof A Ramesh, IIT Guwahati
Expertise: metagenomic DNA isolation, PCR, transformation and cloning experiments
Research Projects
Research Projects
| Sl. No | Name of the Project | Name of the Principal Investigator(PI) | Name of the Co-PI | Name of the Funding Agency | Type (Government/Non-Government) | Year | Funds Sanctioned (INR in lakhs) | Duration of the Project |
|---|---|---|---|---|---|---|---|---|
| 1 | Pharmacogenetic analysis of Cytochrome P450 2D6 (CYP2D6) gene polymorphism in general population of Assam Status: Ongoing |
Dr. Purabi Deka Bose | Cotton University | In House | 2023 | 100000 | 18 months | |
| 2 | Evaluate the role of oxidative stress in HEV related pregnancy complications and outcome: A hospital based study from northeast India Status: Ongoing |
Dr Purabi Deka Bose | ICMR, Govt of India | Government | 2019 | 29.32 Lakh | 3 years | |
| 3 | Delineation of the chromosomal and molecular endocrinological alterations leading to RPL in NE India (Recurrent Pregnancy Loss) Status: Completed |
Dr Purabi Deka Bose | DBT, Govt of India | Government | 2016 | 74.73 lakh | 3 years | |
| 4 | Screening of Genetic and Immunological Factors in Human Papilloma Virus Infection Induced Cervical Cancer: A North East India Based Study Status: Completed |
Dr. Purabi Deka Bose | DBT, Govt of India | Government | 2014 | 33.35 Lakh | 3 years |
Research paper publications
2023
1. Kashyap N, Islam M, Kaur H, Tiwari D, Begum A, Bose M, Das CR, Saikia AK, Kalita P, Bose PD, Bose S, Oxidative stress-A key determinant of complications and negative outcome in hepatitis E virus infected pregnancies, Journal of Medical Virology, 2023 10.1002/jmv.28576
2021
1. Begum A, Mishra A, Das CR, Das S, Dutta R, Kashyap N, Bose PD, Bose S, Impact of TNF-α profile in recurrent pregnancy loss pathogenesis: A patient based study from Assam, J Reprod Immunol, 2021 10.1016/j.jri.2021.103430
2. Tiwari D, Das CR, Sultana R, Kashyap N, Islam M, Bose PD, Saikia AK, Bose S, Increased homocysteine mediated oxidative stress as key determinant of hepatitis E virus (HEV) infected pregnancy complication and outcome: A study from Northeast India, Infection Genetics and Evolution, 2021 10.1016/j.meegid.2021.104882
2020
1. Khan, Mohammad & Tiwari, Diptika & Dongre, Anita & Rehman, Sadaf & Mustafa, Saad & Das, Chandana & Massey, Sheersh & Bose, Purabi & Bose, Sujoy & Husain, Syed, Exploring the p53 connection of cervical cancer pathogenesis involving north-east Indian patients, PLoS ONE, 2020 10.1371/journal.pone.0238500
2. Tiwari D, Ray Das C, Sultana R, Kakoti S, Aasif Khan M, Dongre A, Husain SA, Bose PD, Bose S , Impact of modulation of telomerase and cancer stem-cell marker OCT4 axis in cervical cancer pathogenesis with underlying HPV16 infection, J Cell Biochem, 2020 10.1002/jcb.29501
2019
1. Tiwari D, Ray Das C, Sultana R, Kakoti S, Aasif Khan M, Dongre A, Husain SA, Bose PD, Bose S, Impact of modulation of telomerase and cancer stem-cell marker OCT4 axis in cervical cancer pathogenesis with underlying HPV16 infection, J Cell Biochem, 2019 10.1002/jcb.29501
2018
1. Das CR,Tiwari D,Dongre A, Khan MA, Husain SA, Sarma A,Bose S,Bose PD, Deregulated TNF-Alpha Levels Along with HPV Genotype 16 Infection Are Associated with Patients, 2018 10.1089/vim.2017.0151
2017
1. Tiwari D, Das CR, Bose PD, Bose S, Associative role of TYMS6bpdel polymorphism and resulting hyperhomocysteinemia in the pathogenesis of preterm delivery and associated complications: A study from Northeast India, Gene, 2017 10.1016/j.gene.2017.06.023
2016
1. Tiwari D, Bose PD, Sultana R, Das CR, Bose S, Preterm delivery and associated negative pregnancy outcome - A tale of faulty progesterone receptor signaling pathway and linked derailed immunomodulation: A study from Northeast India, J Reprod Immunol, 2016 10.1016/j.jri.2016.10.001
2015
1. Tiwari D, Bose PD, Das S, Das CR, Datta R, Bose S, MTHFR (C677T) polymorphism and PR (PROGINS) mutation as genetic factors for preterm delivery, fetal death and low birth weight: A Northeast Indian population based study, Meta Gene, 2015 10.1016/j.mgene.2014.12.002
2014
1. Das CR, Deka M, Bose S, Bose PD, Das GC, Demographic profile of Cervical Cancer develop-pment: a hospital based study, International Journal of Medical Research and Review, 2014
2. Bose PD, Das BC, Hazam RK, Kumar A, Medhi S, Kar P, Evidence of extrahepatic replication of hepatitis E virus in human placenta, J Gen Virol, 2014 10.1099/vir.0.063602-0
2013
1. Goel V, Bose PD, Sarma MP, Hazam RK, Das BC, Gondal R, Kar P, Chemokine receptor 5 (CCR5) polymorphism in chronic hepatitis B patients treated with three different nucleos(t)ide analogues, Indian J Med Res, 2013
2011
1. Medhi S, Deka M, Deka P, Swargiary SS, Hazam RK, Sharma MP, Gumma PK, Asim M,Kar P, Promoter region polymorphism & expression profile of toll like receptor-3 (TLR-3) gene in chronic hepatitis C virus (HCV) patients from India, Indian J Med Res, 2011
2. Bose PD, Das BC, Kumar A, Gondal R, Kumar D, Kar P, High viral load and deregulation of the progesterone receptor signaling pathway: association with hepatitis E-related poor pregnancy outcome., Journal of Hepatology, 2011 10.1016/j.jhep.2010.08.037
3. Bose PD, Sarma MP, Medhi S, Das BC, Husain SA, Kar P, Role of polymorphic N-acetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis, J Gastroenterol Hepatol, 2011 DOI: 10.1111/j.1440-1746.2010.06355.x
2010
1. Deka M, Bose M, Baruah B, Bose PD, Medhi S, Bose S, Saikia A, Kar P, Role of CYP2E1 gene polymorphisms association with hepatitis risk in Northeast India, World J Gastroenterol, 2010 DOI: 10.3748/wjg.v16.i38.4800
2008
1. Medhi S, Potukuchi SK, Polipalli SK, Swargiary SS, Deka P, Chaudhary A, Begum N, Hussain Z, Ahlawat RS, Kar P, Diagnostic utility of hepatitis C virus core antigen in hemodialysis patients, 2008 doi: 10.1016/j.clinbiochem.2007.12.024
2005
1. Purabi Deka and MC Kalita , In vitro clonal propagation and oragnogenesis in Spilanthes acmella (L) Murray. A herbal pesticidal plant of Northeast India, Plant Biochemistry and Biotechnology, 2005 https://doi.org/10.1007/BF03263230
Research Scholars
| Sl. No | Name | Research Topic | Roll No |
|---|---|---|---|
| 1 | Natasha Kashyap | Reproductive Biology | MBB1791001 |
| 2 | Snigdha Jyoti Das | Medical Biotechnology | MBB1891001 |
| 3 | Mayuri Goswami | Medical Biotechnology | MBB1991001 |
| 4 | Shantipriya Kakati | Medical Biotechnology | MBB1991002 |
Awards
Awards received:
Received Best poster award in the International conference on Biotech and Bioinformatics held in Pune, Feb, 2015
Received Young Investigator Award For the 2nd best Oral presentation in Indian Society of Gastroenterology Conference (ISGCON), Bengaluru, 2007.
Received Plenary Award in 3rd best paper presentation in the Plenary session of Indian Society of Gastroenterology Conference (ISGCON), Hyderabad 2010
Received Liver Care Foundation Meritorious Award For the paper presented at Asian Pacific Association for the Study of the Liver (APASL) Meeting 2009, Hong Kong
Received Young Investigator Bursary Award for presenting paper in European Association for the Study of the Liver (EASL) Monothematic Congress 2010, Athens
Received Young Investigator Bursary Award for oral presention in the European Association for the Study of the Liver (EASL) Congress, 2012, Barcelona
Summer research fellowship awarded by Indian Academy of Sciences, Bangalore (2003). A research project was carried out on "DNA sequence variants in Human Papilloma Virus and Cervical Cancer" in ‘Molecular oncology lab’ in the Institute of Cytology and Preventive Oncology (ICMR), New Delhi, under the supervision of Dr. Bhudev C Das.
Other Information
Presentation at Institutes/Conferences/Symposia
|
Title/Academic Session/Subject |
Organizing Institution (with City and Country) |
Type of Confere-nce/Seminar/ Workshop (National/ International) |
Date of lecture |
|
"Significance of RANTES Balance in Nonalcoholic Fatty Liver Disease Susceptibility and Severity in Non-obese Non-DM2 Cases: A Pilot from Assam, India" poster presentation in the KDDW, 2019 |
Korea Digestive Disease Week KDDW, 2019 (Seoul, Korea) |
International | 28.11.2019 |
|
"Immunological modes of pregnancy loss: similarity in Hepatitis E infected and non infected pregnancy cases" Poster presentation in the International Congress of Immunology, 2016 |
International Congress of Immunology, 2016 (Australia, Melbourne) |
International | 22.08.2016 |
|
Role of genetic alteration in MTHFR gene and homocysteine levels as critical factors influencing HEV related pregnancy outcome/ Oral presen-tation/ EASL International Liver Congress, 2012 |
European association for the study of the liver (Barcelona, Spain) |
International |
20-04-12 |
|
Role of PIBF and altered cytokine profile in HEV related pregnancy outcome/Poster/ Conference of APASL, 2011 |
Asian Pacific Association for the Study of the liver (Bangkok, Thailand) |
International |
18-02-11 |
|
Role of INOS/NO, NFKB ABD WNT Beta catenin pathway deregulation in ALD-Cirrhosis in NE India /Poster/ EASL monothematic Conference on Alcoholic Liver Disease, 2010 |
European association for the study of the liver (Athens, Greece) |
International |
21/10/10 |
|
Association of progesterone receptor gene with hepatitis E disease severity in pregnancy/Poster/ Conference of APASL, 2009 |
APASL (Hong Kong, China) |
International |
15/02/09 |
|
TNF alpha level are critical in the pathogenesis of HPV-16 infection related cervical neoplasia/ Poster/ International Conference on Biotech-nology and Bioinformatics,ICBB-2015 |
International Conference on Biotechnology and Bioinformatics, ICBB (Pune, India) |
International |
7/02/15 |
|
Deregulation of Progesterone receptor signalling pathway and association with hepatitis E related poor pregnancy outcome/Plenary session/ISGCON, 2010 |
Indian Society of Gastroenterology, ISG (Hyderabad, India) |
National |
24/11/10 |
|
Poor pregnancy outcome in hepatitis E and association of Progins; a haplotype of PR / poster/APDW2008 |
Asia Pacific digestive week 2008, New Delhi, India |
International |
14-09-08 |
|
Evaluation of N-acetyltransferase2 and cytochrome450 2E1 polymorphism as possible risk factor for anti-tuberculosis drug induced hepatitis/ young investigator award session/ISGCON2007 |
Indian Society of Gastroenterology, Bangalore, India |
National |
17-11-07 |
|
Retrospective study of acute viral hepatitis in Delhi: a hospital based study/poster/ INASL 2008 |
Indian National As-sociation for study of liver, 2008, New Delhi, India |
National |
2008 |
|
Poster/INASL, 2009 |
Indian National Association for study of liver, 2009, New Delhi, India |
National |
28-03-09 |
|
Role of N-acetyltransferase2 gene polymorphism as susceptible risk factor of anti-tuberculosis drug induced hepatitis/poster/ISGCON, 2006 |
Indian Society of Gastroenterology, 2006, Mumbai, India |
National |
10-11-2006 |
|
Invitro clonal propagation and organo-genesis in Spilanthes acmella (L)/ poster/ National seminar on Medicinal plant in NE region, 2004 |
National medicinal plant board, Minis-try of Health and FW, Govt. of India, Govt Ayurvedic College, 2004 |
National |
8-10-2004 |
|
Human papilloma virus as the principal aetiological agent for the development of cervical cancer/oral/Annual general meeting and conference, Zoological society of Assam |
Zoological society of Assam, Nalbari, Assam, India |
Regional |
18-01-2004 |
poster
|
1. Invitro clonal propagation and organo-genesis in Spilanthes acmella (L)/ poster/ National seminar on Medicinal plant in NE region, 2004
|
|
2. Role of N-acetyltransferase2 gene polymorphism as susceptible risk factor of anti-tuberculosis drug induced hepatitis/ISGCON, 2006
|